Trial Profile

A Phase 1b Open-Label, Multiple Ascending Dose Study of the Safety, Tolerability, and Biological Activity of Intravitreal THN391 in Diabetic Macular Oedema Secondary to Non-Proliferative Diabetic Retinopathy.

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 20 May 2025

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At a glance

14 May 2025 According to a Therini Bio media release, company announced that supported by the current data and financing, the experienced team at Therini Bio is preparing to begin dosing patients in Phase 1b trials evaluating THN391 in AD and DME.
14 May 2025 According to a Therini Bio media release, company announced a $39 million extension of the Series A financing. The company anticipates using the proceeds to fund Phase 1b trials evaluating its lead candidate, THN391, for the treatment of Alzheimer's Disease (AD) and Diabetic Macular Edema (DME), as well as support development of a fibrin/VEGF bispecific.
19 Dec 2024 Planned initiation date changed from 25 Nov 2024 to 18 Dec 2024.

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