Trial Profile

A Two-Part Study to Examine the Drug-Drug Interaction With Itraconazole and Safety of AZD4041 in Healthy Participants and the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 as an Adjunctive Treatment to Buprenorphine in Participants With Moderate to Severe Opioid Use Disorder

Status: Discontinued

Phase of Trial: Phase I

Latest Information Update: 31 Mar 2025

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At a glance

Drugs AZD 4041 (Primary) ; Buprenorphine; Buprenorphine/naloxone; Hydromorphone; Itraconazole
Indications Opioid-related disorders
Focus Adverse reactions; Pharmacokinetics; Therapeutic Use
Sponsors AstraZeneca

26 Mar 2025 Planned End Date changed from 24 Dec 2025 to 31 Dec 2024.
26 Mar 2025 Planned primary completion date changed from 24 Dec 2025 to 31 Jul 2024.
21 Nov 2024 Status changed from recruiting to discontinued.

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