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A Two-Part Study to Examine the Drug-Drug Interaction With Itraconazole and Safety of AZD4041 in Healthy Participants and the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 as an Adjunctive Treatment to Buprenorphine in Participants With Moderate to Severe Opioid Use Disorder

Trial Profile

A Two-Part Study to Examine the Drug-Drug Interaction With Itraconazole and Safety of AZD4041 in Healthy Participants and the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 as an Adjunctive Treatment to Buprenorphine in Participants With Moderate to Severe Opioid Use Disorder

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 25 Nov 2024

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At a glance

  • Drugs AZD 4041 (Primary) ; Buprenorphine; Buprenorphine/naloxone; Hydromorphone; Itraconazole
  • Indications Opioid-related disorders
  • Focus Adverse reactions; Pharmacokinetics; Therapeutic Use
  • Sponsors AstraZeneca
  • Most Recent Events

    • 21 Nov 2024 Status changed from recruiting to discontinued.
    • 20 Aug 2024 Planned End Date changed from 13 May 2026 to 24 Dec 2025.
    • 20 Aug 2024 Planned primary completion date changed from 13 May 2026 to 24 Dec 2025.

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