Trial Profile

A Phase III, Open-label, Sponsor-blind, Randomized Study of Dato-DXd With or Without Osimertinib Versus Platinum-based Doublet Chemotherapy for Participants With EGFR-mutated Locally Advanced or Metastatic Non-small Cell Lung Cancer Whose Disease Has Progressed on Prior Osimertinib Treatment (TROPION-Lung15)

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 02 May 2025

Price :

$35 ^*

Note:

Adis is an information provider.
Final gross price and currency may vary according to local VAT and billing address.
Your purchase entitles you to full access to the information contained in our trial profile at the time of purchase.
A link to download a PDF version of the trial profile will be included in your email receipt.

At a glance

Drugs Datopotamab deruxtecan (Primary) ; Osimertinib (Primary) ; Carboplatin; Cisplatin; Pemetrexed
Indications Non-small cell lung cancer; Solid tumours
Focus Therapeutic Use
Acronyms TROPION-Lung15
Sponsors AstraZeneca

26 Nov 2024 Planned End Date changed from 31 Dec 2027 to 29 Nov 2027.
26 Nov 2024 Planned primary completion date changed from 30 Jun 2026 to 11 Jun 2026.
30 Oct 2024 According to a Daiichi Sankyo media release, first patient has been dosed.

If your organization or you do not have a subscription, try one of the following:

Contacting your organization’s admin about adding this content to your AdisInsight subscription
Buying a PDF version of any individual profile
Request a free trial (opens in a new window)

If your organization has a subscription, there are several access options, even while working remotely:

Working within your organization’s network
Login with username/password or try to access via your institution
Persisted access using your organization’s identifier stored in your user browser for 90 days

For assistance, contact us at asktheexpert.adisinsight@springer.com