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A Combined Single and Multiple Ascending Dose Phase 1a/1b, Double-blind, Placebo-Controlled, and Food-effect Study to Evaluate the Safety and Pharmacokinetics of Oral KM-023 in Healthy Participants. Followed by a 3-month Open Label Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Oral KM-023 in Olmsted Syndrome Patients

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Trial Profile

A Combined Single and Multiple Ascending Dose Phase 1a/1b, Double-blind, Placebo-Controlled, and Food-effect Study to Evaluate the Safety and Pharmacokinetics of Oral KM-023 in Healthy Participants. Followed by a 3-month Open Label Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Oral KM-023 in Olmsted Syndrome Patients

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 02 Sep 2025

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At a glance

  • Drugs Ainuovirine (Primary)
  • Indications Congenital disorders; Palmoplantar keratoderma; Skin disorders
  • Focus Adverse reactions; First in man
  • Sponsors Kamari Pharma

Most Recent Events

  • 03 Jun 2025 According to Kamari Pharma media release, company announced the closing of a $23 million Series A financing. The round was co-led by new investor BRM Group and existing investor Pontifax with participation from additional investors. Proceeds will be used to advance lead program KM023 a first-in-class oral TRPV3 inhibitor, into clinical development for the treatment of three rare genetic skin diseases, Olmsted syndrome, severe keratoderma and ichthyosis.
  • 23 May 2024 New trial record

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