Trial Profile

A Randomized, Phase 3, Open-label Study of Neoadjuvant Darovasertib in Subjects With Primary Non-metastatic Uveal Melanoma (OptimUM-10)

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 04 Feb 2026

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At a glance

Drugs Darovasertib (Primary)
Indications Uveal melanoma
Focus Registrational; Therapeutic Use
Acronyms OptimUM-10
Sponsors IDEAYA Biosciences

Most Recent Events

11 Jan 2026 According to an IDEAYA Biosciences media release, complete full enrollment of approximately 450 patients across enucleation and plaque brachytherapy cohorts by H1 '27.
15 Sep 2025 Planned End Date changed from 7 Dec 2027 to 1 Mar 2031.
15 Sep 2025 Planned primary completion date changed from 7 May 2027 to 1 Oct 2030.

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