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A Pilot Clinical Trial of Vemurafenib and Cobimetinib as a Redifferentiation Strategy in High-Risk, Radioactive Iodine (RAI) Naïve, BRAFV600E Mutated Differentiated Thyroid Carcinoma Patients Undergoing Initial RAI Therapy

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Trial Profile

A Pilot Clinical Trial of Vemurafenib and Cobimetinib as a Redifferentiation Strategy in High-Risk, Radioactive Iodine (RAI) Naïve, BRAFV600E Mutated Differentiated Thyroid Carcinoma Patients Undergoing Initial RAI Therapy

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 07 Dec 2025

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At a glance

  • Drugs Vemurafenib (Primary) ; Thyrotropin alfa
  • Indications Carcinoma; Thyroid cancer
  • Focus Therapeutic Use

Most Recent Events

  • 02 Dec 2024 Planned End Date changed from 30 Nov 2026 to 22 Nov 2026.
  • 02 Dec 2024 Planned primary completion date changed from 30 Nov 2026 to 22 Nov 2026.
  • 11 Jun 2024 New trial record

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