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A Phase 1 Open-Label Study of PF-07934040 as a Single Agent and in Combination With Other Targeted Agents in Participants With Advanced Solid Tumors Harboring Mutations in the KRAS Gene

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Trial Profile

A Phase 1 Open-Label Study of PF-07934040 as a Single Agent and in Combination With Other Targeted Agents in Participants With Advanced Solid Tumors Harboring Mutations in the KRAS Gene

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 11 Mar 2025

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At a glance

  • Drugs Bevacizumab (Primary) ; Carboplatin (Primary) ; Cetuximab (Primary) ; Cisplatin (Primary) ; Fluorouracil (Primary) ; Folinic acid (Primary) ; Gemcitabine (Primary) ; Oxaliplatin (Primary) ; Paclitaxel (Primary) ; Pembrolizumab (Primary) ; Pemetrexed (Primary) ; PF 07934040 (Primary)
  • Indications Adenocarcinoma; Colorectal cancer; Non-small cell lung cancer; Pancreatic cancer; Pancreatic ductal carcinoma; Solid tumours
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Pfizer

    • Most Recent Events

    • 04 Feb 2025 Planned End Date changed from 7 Jun 2028 to 29 Jul 2028.
    • 04 Feb 2025 Planned primary completion date changed from 8 Jun 2027 to 30 Jul 2027.
    • 30 Sep 2024 Planned End Date changed from 14 Jun 2028 to 7 Jun 2028.

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