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Phase 1, Open-Label, Single Center Study of KYV-101, an Autologous Fully-Human Anti-CD19 Chimeric Antigen Receptor T Cell (CD19 CAR T) Therapy, in Participants With Treatment Refractory Progressive Multiple Sclerosis

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Trial Profile

Phase 1, Open-Label, Single Center Study of KYV-101, an Autologous Fully-Human Anti-CD19 Chimeric Antigen Receptor T Cell (CD19 CAR T) Therapy, in Participants With Treatment Refractory Progressive Multiple Sclerosis

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 03 Feb 2026

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At a glance

  • Drugs Mivocabtagene autoleucel (Primary) ; Cyclophosphamide; Fludarabine
  • Indications Multiple sclerosis
  • Focus Adverse reactions; Pharmacokinetics

Most Recent Events

  • 23 Jan 2026 Planned End Date changed from 1 Jun 2027 to 1 Feb 2027.
  • 23 Jan 2026 Planned primary completion date changed from 1 Jun 2026 to 1 Feb 2026.
  • 24 Sep 2025 Results presented in the Kyverna Therapeutics Media Release.

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