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Phase 1, Open-Label, Single Center Study of KYV-101, an Autologous Fully-Human Anti-CD19 Chimeric Antigen Receptor T Cell (CD19 CAR T) Therapy, in Participants with Treatment Refractory Progressive Multiple Sclerosis

Trial Profile

Phase 1, Open-Label, Single Center Study of KYV-101, an Autologous Fully-Human Anti-CD19 Chimeric Antigen Receptor T Cell (CD19 CAR T) Therapy, in Participants with Treatment Refractory Progressive Multiple Sclerosis

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 27 May 2025

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At a glance

  • Drugs KYV-101 (Primary) ; Cyclophosphamide; Fludarabine
  • Indications Multiple sclerosis
  • Focus Adverse reactions; Pharmacokinetics

Most Recent Events

  • 01 Mar 2025 According to Results presented at the Americas Committee for Treatment and Research in Multiple Sclerosis Forum, trial will continue enrolling participants, the study is expected to complete in 2026.
  • 20 Jan 2025 Status changed from recruiting to active, no longer recruiting.
  • 10 Dec 2024 Trial design presented at the 66th American Society of Hematology Annual Meeting and Exposition.

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