Trial Profile

Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors: a Phase I/II Study

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 13 Oct 2025

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At a glance

Drugs Pemetrexed (Primary) ; Toripalimab (Primary)
Indications Meningeal carcinomatosis; Solid tumours
Focus Adverse reactions; Therapeutic Use

Most Recent Events

29 Sep 2025 Planned End Date changed from 30 Apr 2026 to 30 Jul 2026.
29 Sep 2025 Status changed from recruiting to active, no longer recruiting.
19 Mar 2025 Planned End Date changed from 20 Jun 2026 to 30 Apr 2026.

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