Trial Profile

Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors: a Phase I/II Study

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 27 May 2026

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At a glance

Drugs Pemetrexed (Primary) ; Toripalimab (Primary)
Indications Meningeal carcinomatosis; Solid tumours
Focus Adverse reactions; Therapeutic Use

Most Recent Events

11 May 2026 Planned End Date changed from 30 Jul 2026 to 31 Jul 2026.
11 May 2026 Planned primary completion date changed from 30 Jan 2026 to 31 Jul 2026.
29 Sep 2025 Planned End Date changed from 30 Apr 2026 to 30 Jul 2026.

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