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A Phase 1a/1b Study of LY4052031, an Antibody-Drug Conjugate Targeting Nectin-4, in Participants With Advanced or Metastatic Urothelial Carcinoma or Other Solid Tumors

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Trial Profile

A Phase 1a/1b Study of LY4052031, an Antibody-Drug Conjugate Targeting Nectin-4, in Participants With Advanced or Metastatic Urothelial Carcinoma or Other Solid Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 24 Jan 2026

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At a glance

  • Drugs LY 4052031 (Primary)
  • Indications Advanced breast cancer; Carcinoma; Cervical cancer; Gastric cancer; Head and neck cancer; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Prostate cancer; Solid tumours; Squamous cell cancer; Triple negative breast cancer; Urogenital cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms NEXUS-01
  • Sponsors Eli Lilly and Company

Most Recent Events

  • 20 Aug 2025 Status changed from suspended to recruiting.
  • 24 Apr 2025 Status changed from recruiting to suspended. Reason the study was stopped: The study was paused due to sponsor decision.
  • 29 Jan 2025 Planned number of patients changed from 220 to 420.

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