Trial Profile

A Randomized, Double-Blind, Placebo-Controlled Multicenter Phase III Study to Assess Efficacy and Safety of Ropeginterferon Alfa-2b (P1101) in Adult Patients With Pre-fibrotic/Early Primary Myelofibrosis (PMF) or Overt PMF at Low or Intermediate-1 Risk According to DIPSS Plus (HOPE-PMF): The Core Study and Its Extension Study

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 31 Dec 2025

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At a glance

15 Dec 2025 According to a PharmaEssentia Corporation media release, global enrollment in the phase 3 trial for early PMF is ongoing, with completion of enrollment expected in H1 2026.
13 Aug 2025 Planned End Date changed from 1 Apr 2028 to 30 Sep 2028.
13 Aug 2025 Planned primary completion date changed from 1 Mar 2027 to 30 Sep 2027.

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