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Corticodependent or Corticoresistant Brain Radionecrosis After Radiotherapy for Brain Metastases: a Multicentre Randomized, Controlled Double-blind Phase III Study, Comparing Bevacizumab Versus Placebo

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Trial Profile

Corticodependent or Corticoresistant Brain Radionecrosis After Radiotherapy for Brain Metastases: a Multicentre Randomized, Controlled Double-blind Phase III Study, Comparing Bevacizumab Versus Placebo

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 29 Sep 2025

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At a glance

  • Drugs Bevacizumab (Primary) ; Prednisolone; Prednisolone
  • Indications Brain metastases
  • Focus Therapeutic Use
  • Acronyms BRADI

Most Recent Events

  • 17 Aug 2025 Planned primary completion date changed from 1 Mar 2028 to 1 Aug 2028.
  • 13 Aug 2025 Status changed from not yet recruiting to recruiting.
  • 01 Aug 2025 Planned End Date changed from 1 Dec 2029 to 1 Aug 2030.

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