Trial Profile

Early Treatment Intensification in Patients With High Risk Mantle Cell Lymphoma Using CAR-T-cell Treatment After an Abbreviated Induction Therapy With Rituximab and Ibrutinib and 6 Months Ibrutinib Maintenance (Arm A) as Compared to Standard of Care Induction and Maintenance (Arm B)

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 22 Sep 2025

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At a glance

Drugs Brexucabtagene autoleucel (Primary) ; Ibrutinib (Primary) ; Bendamustine; Carmustine; Cisplatin; Cyclophosphamide; Cytarabine; Dexamethasone; Dexamethasone; Doxorubicin; Etoposide; Filgrastim; Fludarabine; Melphalan; Oxaliplatin; Pegfilgrastim; Prednisolone; Prednisolone; Prednisone; Rituximab; Thiotepa; Tocilizumab; Vincristine
Indications Mantle-cell lymphoma
Focus Therapeutic Use
Acronyms CARMAN

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