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A Phase I Randomized, Single-blind, Placebo-controlled, and Sequential Group Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 Following Single and Multiple Ascending Doses Via Intravenous Administration, and an Open-label, 2-Period, 2-Sequence, Cross-over Study to Assess the Effects of Intravenous AZD4144 on Rosuvastatin Pharmacokinetics in Healthy Participants

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Trial Profile

A Phase I Randomized, Single-blind, Placebo-controlled, and Sequential Group Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 Following Single and Multiple Ascending Doses Via Intravenous Administration, and an Open-label, 2-Period, 2-Sequence, Cross-over Study to Assess the Effects of Intravenous AZD4144 on Rosuvastatin Pharmacokinetics in Healthy Participants

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 08 Apr 2025

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At a glance

  • Drugs AZD 4144 (Primary) ; Rosuvastatin (Primary)
  • Indications Cardiovascular disorders; Kidney disorders
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors AstraZeneca

    • Most Recent Events

    • 03 Apr 2025 Planned End Date changed from 2 May 2025 to 2 Jul 2025.
    • 03 Apr 2025 Planned primary completion date changed from 2 May 2025 to 2 Jul 2025.
    • 19 Feb 2025 Planned End Date changed from 2 Apr 2025 to 2 May 2025.

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