Trial Profile

An Open Label, Multicenter, Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Profile of the PARP1 Inhibitor M9466 in Combination With Topoisomerase 1 Inhibitor-based Regimens in Advanced Solid Tumors and Colorectal Cancer (DDRiver 511)

Status: Suspended

Phase of Trial: Phase I

Latest Information Update: 04 Mar 2025

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At a glance

Drugs Bevacizumab (Primary) ; Fluorouracil (Primary) ; Folinic acid (Primary) ; HRS-1167 (Primary) ; Irinotecan (Primary)
Indications Colorectal cancer; Solid tumours
Focus Adverse reactions
Acronyms DDRiver 511
Sponsors EMD Serono Research & Development Institute

26 Feb 2025 Status changed from recruiting to suspended.
16 Oct 2024 Status changed from not yet recruiting to recruiting.
30 Sep 2024 Planned initiation date changed from 16 Sep 2024 to 10 Oct 2024.

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