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Selinexor in Combination With R-CHOP as the First-line Therapy for TP53-mutated DLBCL Patients: a Single-arm, Multicenter, Phase II Clinical Trial (Smart Trial)

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Trial Profile

Selinexor in Combination With R-CHOP as the First-line Therapy for TP53-mutated DLBCL Patients: a Single-arm, Multicenter, Phase II Clinical Trial (Smart Trial)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 17 Feb 2026

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At a glance

  • Drugs Selinexor (Primary) ; Cyclophosphamide; Doxorubicin; Prednisone; Rituximab; Vincristine
  • Indications Diffuse large B cell lymphoma
  • Focus Therapeutic Use
  • Acronyms Smart Trial

Most Recent Events

  • 12 Feb 2026 Planned End Date changed from 1 Apr 2028 to 1 Jan 2027.
  • 29 Jul 2024 New trial record

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