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A Phase 2, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of RAP-219 for the Acute Treatment of Manic Episodes, With or Without Mixed Features, Associated With Bipolar I Disorder

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Trial Profile

A Phase 2, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of RAP-219 for the Acute Treatment of Manic Episodes, With or Without Mixed Features, Associated With Bipolar I Disorder

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 29 Oct 2026

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At a glance

  • Drugs RAP 219 (Primary)
  • Indications Bipolar disorders
  • Focus Proof of concept; Therapeutic Use
  • Sponsors Rapport Therapeutics

Most Recent Events

  • 26 Oct 2026 Status changed from active, no longer recruiting to completed.
  • 20 Oct 2026 Primary endpoint (Young Mania Rating Scale (YMRS)) has been met, according to a Rapport Therapeutics media release.
  • 20 Oct 2026 Results presented in a Rapport Therapeutics Media Release.

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