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A Phase 1, Open-Label, Fixed-Sequence Study to Evaluate the Effect of Itraconazole and Cyclosporine on the Single-Dose Pharmacokinetics of Danuglipron in Healthy Adult Participants

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Trial Profile

A Phase 1, Open-Label, Fixed-Sequence Study to Evaluate the Effect of Itraconazole and Cyclosporine on the Single-Dose Pharmacokinetics of Danuglipron in Healthy Adult Participants

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 19 Aug 2025

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At a glance

  • Drugs Ciclosporin (Primary) ; Danuglipron (Primary) ; Itraconazole (Primary)
  • Indications Obesity; Type 2 diabetes mellitus
  • Focus Pharmacokinetics
  • Sponsors Pfizer

Most Recent Events

  • 14 Apr 2025 Status changed from active, no longer recruiting to discontinued.
  • 28 Mar 2025 Planned End Date changed from 14 Mar 2025 to 30 Jun 2025.
  • 28 Mar 2025 Planned primary completion date changed from 14 Mar 2025 to 30 Jun 2025.

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