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A Multicenter, Open-label, First-in-Human Study of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

Trial Profile

A Multicenter, Open-label, First-in-Human Study of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 09 May 2025

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At a glance

  • Drugs TYRA 430 (Primary)
  • Indications Liver cancer; Solid tumours
  • Focus Adverse reactions; First in man
  • Acronyms SURF431
  • Sponsors Tyra Biosciences

Most Recent Events

  • 09 Apr 2025 Status changed from planning to recruiting.
  • 27 Mar 2025 According to Tyra Biosciences media release, company expects to dose in this trial in Q2 2025.
  • 22 Jan 2025 According to Tyra Biosciences media release, abstract from this study is accepted for presentation at the 2025 ASCO Gastrointestinal Cancers Symposium (ASCO GI), taking place January 23-25, 2025, in San Francisco, CA. Data from this study will be presented in Poster Session B on January 24, 2025, 11:30 AM - 1:00 PM PST.

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