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A Modular Phase I/II Open-label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With Relapsed or Refractory B-Cell Malignancies (TITANium)

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Trial Profile

A Modular Phase I/II Open-label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With Relapsed or Refractory B-Cell Malignancies (TITANium)

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 22 Jan 2025

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At a glance

  • Drugs AZD 5492 (Primary)
  • Indications Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Mantle-cell lymphoma
  • Focus Adverse reactions
  • Acronyms TITANium
  • Sponsors AstraZeneca

    • Most Recent Events

    • 17 Jan 2025 Planned End Date changed from 16 Feb 2028 to 14 Feb 2028.
    • 17 Jan 2025 Planned primary completion date changed from 16 Feb 2028 to 14 Feb 2028.
    • 24 Sep 2024 Planned End Date changed from 17 Feb 2028 to 16 Feb 2028.

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