Trial Profile

A Phase I, Open-label, 2 Part, Fixed Sequence Study to Assess the Effect of Co-administration of Camizestrant (AZD9833) on the Pharmacokinetics of Midazolam Exposure (CYP3A4/5 Substrate) and of Carbamazepine (CYP3A4/5 Inducer) on Camizestrant Exposure in Healthy Post Menopausal Female Participants

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 03 Jun 2025

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At a glance

Drugs Camizestrant (Primary) ; Carbamazepine (Primary) ; Midazolam (Primary)
Indications HER2 negative breast cancer
Focus Pharmacokinetics
Sponsors AstraZeneca

29 May 2025 Planned number of patients changed from 40 to 50.
29 May 2025 Planned End Date changed from 11 Jul 2025 to 30 Jul 2025.
29 May 2025 Planned primary completion date changed from 11 Jul 2025 to 30 Jul 2025.

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