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A Phase I/II Trial of MB-dNPM1-TCR.1 in HLA-A*02:01-positive Patients with Relapsed or Refractory NPM1-mutated AML to Determine Safety and Obtain First Data on Efficacy

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Trial Profile

A Phase I/II Trial of MB-dNPM1-TCR.1 in HLA-A*02:01-positive Patients with Relapsed or Refractory NPM1-mutated AML to Determine Safety and Obtain First Data on Efficacy

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 29 Aug 2025

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At a glance

  • Drugs MB-dNPM1-TCR.1 (Primary)
  • Indications Acute myeloid leukaemia
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Miltenyi Biotec GmbH

Most Recent Events

  • 10 Jun 2025 Planned number of patients changed from 29 to 32.
  • 22 Aug 2024 New trial record

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