Trial Profile

An Open-label, Non-randomised, Fixed-sequence, Two Period, Phase I Trial to Evaluate the Effect of Different Doses of BI 456906 (Survodutide) on the Single Dose Pharmacokinetics of Bupropion, Caffeine and Midazolam on Otherwise Healthy Volunteers With Overweight or Obesity

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 12 Jan 2026

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At a glance

Drugs Survodutide (Primary) ; Bupropion; Caffeine; Midazolam
Indications Liver cirrhosis; Non-alcoholic steatohepatitis; Obesity; Type 2 diabetes mellitus
Focus Pharmacokinetics
Sponsors Boehringer Ingelheim

09 Jan 2026 Status changed from active, no longer recruiting to completed.
27 Jun 2025 Planned End Date changed from 12 Nov 2025 to 5 Jan 2026.
27 Jun 2025 Planned primary completion date changed from 12 Nov 2025 to 5 Jan 2026.

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