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A Non-Randomized, Open-label Phase II Trial Testing the Activity of XL092 (Zanzalintinib) in Patients With Advanced Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma

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Trial Profile

A Non-Randomized, Open-label Phase II Trial Testing the Activity of XL092 (Zanzalintinib) in Patients With Advanced Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 29 Jun 2026

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At a glance

  • Drugs Zanzalintinib (Primary)
  • Indications Ewing's sarcoma; Leiomyosarcoma; Osteosarcoma; Soft tissue sarcoma; Solid tumours; Synovial sarcoma
  • Focus Therapeutic Use

Most Recent Events

  • 18 Jun 2026 Planned number of patients changed from 29 to 73.
  • 18 Jun 2026 Planned End Date changed from 1 Jul 2029 to 1 Jul 2033.
  • 16 Jul 2025 Planned End Date changed from 1 Jul 2026 to 1 Jul 2029.

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