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RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-MASKED STUDY OF THE SAFETY AND EFFICACY OF POS (0.75% PHENTOLAMINE OPHTHALMIC SOLUTION) IN PARTICIPANTS WITH PREVIOUS KERATOREFRACTIVE SURGERY WITH DECREASED VISUAL ACUITY UNDER MESOPIC CONDITIONS

Trial Profile

RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-MASKED STUDY OF THE SAFETY AND EFFICACY OF POS (0.75% PHENTOLAMINE OPHTHALMIC SOLUTION) IN PARTICIPANTS WITH PREVIOUS KERATOREFRACTIVE SURGERY WITH DECREASED VISUAL ACUITY UNDER MESOPIC CONDITIONS

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 08 Oct 2025

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At a glance

  • Drugs Phentolamine (Primary)
  • Indications Nyctalopia
  • Focus Registrational; Therapeutic Use
  • Acronyms LYNX-3
  • Sponsors Ocuphire Pharma

Most Recent Events

  • 04 Sep 2025 According to an Opus Genetics media release, LYNX-3 is the second of two, pivotal Phase 3 studies and follows the same study design and patient population as the first study, LYNX-2- for chronic night driving impairment in keratorefractive patients with reduced mesopic vision. These studies have Fast Track designation from the USFDA and are being conducted under a Special Protocol Assessment (SPA).
  • 04 Sep 2025 According to an Opus Genetics media release, 1st patient has been dosed in this trial.
  • 02 Jun 2025 According to an Viatris Pharma media release, this LYNX-3 is anticipated to start shortly with results expected in the first half of 2026

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