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A Multinational, Multicenter Study With an Open-Label Phase 1b and a Randomized, Double-Blind, Placebo-Controlled Phase 3 Followed by an Open-Label Extension to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of Radiprodil in Participants With GRIN-Related Neurodevelopmental Disorder

Trial Profile

A Multinational, Multicenter Study With an Open-Label Phase 1b and a Randomized, Double-Blind, Placebo-Controlled Phase 3 Followed by an Open-Label Extension to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of Radiprodil in Participants With GRIN-Related Neurodevelopmental Disorder

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 21 May 2026

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At a glance

  • Drugs Radiprodil (Primary)
  • Indications Behavioural disorders; Neurodevelopmental disorders; Seizures
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms Beeline
  • Sponsors GRIN Therapeutics

Most Recent Events

  • 04 May 2026 According to a GRIN Therapeutics media release, further EU countries are anticipated to come online in September 2026.
  • 04 May 2026 According to a GRIN Therapeutics media release, based on the results of phase 1b/2a Honeycomb trial, this phase 3 Beeline trial will be initiated, and the findings from the honeycomb study informed the design of the Beeline phase 3 trial.
  • 04 May 2026 According to a GRIN Therapeutics media release, company announced the initiation of its pivotal Phase 3 Beeline study in Europe and already enrolling in the United States and the United Kingdom.

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