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A Phase 3, Randomized, Double-Blind, Active-Controlled Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 in Healthy Subjects 50 Years of Age and Older With Immunobridging to Subjects 18-49 Years of Age

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Trial Profile

A Phase 3, Randomized, Double-Blind, Active-Controlled Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 in Healthy Subjects 50 Years of Age and Older With Immunobridging to Subjects 18-49 Years of Age

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 23 Dec 2025

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At a glance

  • Drugs VAX 31 (Primary)
  • Indications Pneumococcal infections
  • Focus Adverse reactions; Pharmacodynamics; Registrational
  • Sponsors Vaxcyte

Most Recent Events

  • 05 Nov 2025 According to a Vaxcyte media release, the trial is expected to be initiated in 2026 and anticipates to announce data in 2027.
  • 06 Aug 2025 According to a Vaxcyte media release, subject to the results of the Phase 3 studies, which are expected to read out in 2026 and 2027, the Company plans to submit a BLA shortly following the completion of the last Phase 3 study.
  • 06 Aug 2025 According to a Vaxcyte media release, Initiation of the remaining Phase 3 studies, which are shorter in duration than the non-inferiority study, is planned for 2025 and 2026.

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