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A Phase 1/2, Open-label, Multicenter, FIH Study to Evaluate the Safety, Tolerability, PK and Anti-tumor Activity of YH42946 in Patients With Locally Advanced or Metastatic Solid Tumors With HER2 Aberration and EGFR Exon 20 Insertion

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Trial Profile

A Phase 1/2, Open-label, Multicenter, FIH Study to Evaluate the Safety, Tolerability, PK and Anti-tumor Activity of YH42946 in Patients With Locally Advanced or Metastatic Solid Tumors With HER2 Aberration and EGFR Exon 20 Insertion

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 25 Aug 2026

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At a glance

  • Drugs YH 42946 (Primary)
  • Indications Non-small cell lung cancer; Solid tumours
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Yuhan

Most Recent Events

  • 17 Aug 2026 Planned number of patients changed from 161 to 201.
  • 14 Nov 2024 Status changed from not yet recruiting to recruiting.
  • 07 Oct 2024 New trial record

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