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A Phase I/II, Open-Label, Multicenter Study of ALE.P02 (Claudin-1 Targeted Antibody-Drug Conjugate) As a Monotherapy in Adult Patients with Selected Advanced or Metastatic CLDN1+Squamous Solid Tumors

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Trial Profile

A Phase I/II, Open-Label, Multicenter Study of ALE.P02 (Claudin-1 Targeted Antibody-Drug Conjugate) As a Monotherapy in Adult Patients with Selected Advanced or Metastatic CLDN1+Squamous Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 30 Dec 2024

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At a glance

  • Drugs ALE P02 (Primary)
  • Indications Cervical cancer; Head and neck cancer; Oesophageal cancer; Solid tumours; Squamous cell cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Alentis Therapeutics

    • Most Recent Events

    • 12 Nov 2024 According to an Alentis Therapeutics media release, the $181.4 million Series D financing supporting this trial, was led by OrbiMed with co-leads Novo Holdings and Jeito Capital and strengthened by substantial contributions from Frazier Life Sciences, Longitude Capital, RA Capital, and Catalio Capital, among others.
    • 12 Nov 2024 According to an Alentis Therapeutics media release, company has co-led a $181.4 million Series D financing in Alentis Therapeutics. This financing will enable Alentis to begin Phase 1/2 trials for two first-in-class ADCs: ALE.P02, which targets advanced or metastatic CLDN1+ squamous solid tumours with a tubulin inhibitor payload, and ALE.P03, which targets CLDN1+ tumours with a distinct topoisomerase I inhibitor payload.
    • 09 Oct 2024 New trial record

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