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A Phase 1/2 Trial of the Doublet Combination of Avutometinib and Defactinib and As a Triplet in Combination with Temozolomide in Patients with High Grade Malignant Brain Tumours Within the 5G Platform

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A Phase 1/2 Trial of the Doublet Combination of Avutometinib and Defactinib and As a Triplet in Combination with Temozolomide in Patients with High Grade Malignant Brain Tumours Within the 5G Platform

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 28 Jan 2025

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At a glance

  • Drugs Avutometinib (Primary) ; Defactinib (Primary) ; Temozolomide (Primary)
  • Indications Astrocytoma; Glioblastoma; Glioma
  • Focus Adverse reactions; Proof of concept; Therapeutic Use
  • Acronyms 5G-RUBY

    • Most Recent Events

    • 07 Nov 2024 Planned initiation (estimated date of first participant enrollment) date changed from 1 Oct 2024 to 4 Nov 2024.
    • 14 Oct 2024 New trial record

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