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A Prospective, Open-Label, Randomized, Phase 3 Trial of Acasunlimab (GEN1046) in Combination With Pembrolizumab Versus Docetaxel in Subjects With PD-L1 Positive Metastatic Non-Small Cell Lung Cancer After Treatment With a PD-1/PD-L1 Inhibitor and Platinum-Containing Chemotherapy (ABBIL1TY NSCLC-06)

Trial Profile

A Prospective, Open-Label, Randomized, Phase 3 Trial of Acasunlimab (GEN1046) in Combination With Pembrolizumab Versus Docetaxel in Subjects With PD-L1 Positive Metastatic Non-Small Cell Lung Cancer After Treatment With a PD-1/PD-L1 Inhibitor and Platinum-Containing Chemotherapy (ABBIL1TY NSCLC-06)

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 08 Jan 2026

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At a glance

  • Drugs Acasunlimab (Primary) ; Pembrolizumab (Primary) ; Docetaxel
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms ABBIL1TY NSCLC-06
  • Sponsors Genmab

Most Recent Events

  • 29 Dec 2025 Status changed from recruiting to discontinued, according to Genmab media release. This decision reflects prioritization of higher impact opportunities across Genmabs late stage pipeline and increasingly competitive landscape.
  • 04 Nov 2024 Planned initiation date changed from 31 Oct 2024 to 30 Nov 2024.
  • 16 Oct 2024 New trial record

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