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Open-label, cohort-sequential dose-escalation and dose-confirmation Phase 1/2 clinical trial to evaluate the safety and efficacy of domatinostat in combination with sirolimus in adolescents and adults with advanced sarcoma and osteosarcoma

Trial Profile

Open-label, cohort-sequential dose-escalation and dose-confirmation Phase 1/2 clinical trial to evaluate the safety and efficacy of domatinostat in combination with sirolimus in adolescents and adults with advanced sarcoma and osteosarcoma

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 29 Jul 2026

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At a glance

  • Drugs Domatinostat/Sirolimus (Primary)
  • Indications Osteosarcoma; Sarcoma
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 22 Jul 2026 According to Healx media release, Amy Armstrong, M.D., Principal Investigator of the trial.
  • 22 Jul 2026 Status changed from planning to recruiting.
  • 22 Jul 2026 According to Healx media release, first patient has been dosed in this study.

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