Trial Profile

A Phase 2 Multicenter, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Combination Therapy of BRII-179, BRII-835 and Pegylated Interferon Alpha (PEG-IFNα) in Participants With Chronic Hepatitis B Virus (HBV) Infection (ENHANCE)

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 15 Apr 2026

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At a glance

Drugs Elebsiran (Primary) ; Peginterferon alfa (Primary) ; VBI 2601 (Primary)
Indications Hepatitis B
Focus Adverse reactions; Therapeutic Use
Acronyms ENHANCE
Sponsors Brii Biosciences

19 Mar 2026 According to Brii Biosciences media release, results from ENRICH and ENHANCE studies are expected to inform future registrational development decisions.
19 Mar 2026 According to Brii Biosciences media release, this trial is now fully enrolled, with results expected in 2H 2026.
19 Mar 2026 According to Brii Biosciences media release, status changed from recruiting to active, no longer recruiting.

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