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A Randomized, Double-Blinded, Placebo-Controlled, Phase 2, Parallel-Group Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Efgartigimod PH20 SC in Adult Participants with Systemic Sclerosis

Trial Profile

A Randomized, Double-Blinded, Placebo-Controlled, Phase 2, Parallel-Group Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Efgartigimod PH20 SC in Adult Participants with Systemic Sclerosis

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 26 Sep 2026

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At a glance

  • Drugs Efgartigimod alfa (Primary)
  • Indications Systemic scleroderma
  • Focus Therapeutic Use
  • Acronyms eSScape
  • Sponsors argenx

Most Recent Events

  • 03 Jun 2026 According to an argenx media release, the presentation of the Phase 2 eSScape study design will be presented at the at EULAR 2026 held on Friday, June 5 at 16:30 BST
  • 20 Apr 2026 Planned End Date changed from 14 Jun 2027 to 1 Sep 2027.
  • 20 Apr 2026 Planned primary completion date changed from 17 Aug 2026 to 1 Feb 2027.

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