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A Randomized Phase 2 Trial of ASTX727 +/- Iadademstat in Accelerated/Blast-Phase Philadelphia Chromosome-Negative Myeloproliferative Neoplasms (MPNs)

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Trial Profile

A Randomized Phase 2 Trial of ASTX727 +/- Iadademstat in Accelerated/Blast-Phase Philadelphia Chromosome-Negative Myeloproliferative Neoplasms (MPNs)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 03 Sep 2026

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At a glance

  • Drugs Cedazuridine/decitabine (Primary) ; Iadademstat
  • Indications Essential thrombocythaemia; Myelofibrosis; Myeloproliferative disorders; Polycythaemia vera
  • Focus Therapeutic Use

Most Recent Events

  • 11 Aug 2026 Planned number of patients changed from 62 to 78.
  • 11 Aug 2026 Status changed from suspended to recruiting.
  • 29 May 2026 Status changed from recruiting to suspended.

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