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A Randomized Phase 2 Trial of ASTX727 +/- Iadademstat in Accelerated/Blast-Phase Philadelphia Chromosome-Negative Myeloproliferative Neoplasms (MPNs)

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Trial Profile

A Randomized Phase 2 Trial of ASTX727 +/- Iadademstat in Accelerated/Blast-Phase Philadelphia Chromosome-Negative Myeloproliferative Neoplasms (MPNs)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 20 Jun 2025

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At a glance

  • Drugs Cedazuridine/decitabine (Primary) ; Iadademstat
  • Indications Essential thrombocythaemia; Myelofibrosis; Myeloproliferative disorders; Polycythaemia vera
  • Focus Therapeutic Use

Most Recent Events

  • 21 May 2025 Planned number of patients changed from 56 to 62.
  • 21 May 2025 Planned End Date changed from 1 Jun 2027 to 31 Dec 2027.
  • 21 May 2025 Planned primary completion date changed from 1 Jun 2027 to 31 Dec 2027.

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