Trial Profile

Phase 1 Study of a SOS1 Inhibitor, BAY 3498264, in Combination in Participants With Advanced KRASG12C-mutated Solid Tumors

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 25 Sep 2025

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At a glance

Drugs BAY-3498264 (Primary) ; Sotorasib (Primary)
Indications Solid tumours
Focus Adverse reactions; First in man; Pharmacokinetics
Sponsors Bayer

Most Recent Events

22 Jul 2025 Planned End Date changed from 5 Nov 2027 to 7 Mar 2028.
22 Jul 2025 Planned primary completion date changed from 4 Jan 2027 to 31 Jul 2027.
15 Nov 2024 Status changed from not yet recruiting to recruiting.

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