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A Phase 1, Randomized, Double-blind, Placebo-controlled Study of Ascending Doses of WVE-007 to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Adults Living with Overweight or Obesity

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Trial Profile

A Phase 1, Randomized, Double-blind, Placebo-controlled Study of Ascending Doses of WVE-007 to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Adults Living with Overweight or Obesity

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 10 Apr 2026

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At a glance

  • Drugs WVE 007 (Primary)
  • Indications Obesity; Overweight
  • Focus Adverse reactions; First in man; Proof of concept
  • Acronyms INLIGHT
  • Sponsors WaVe life Sciences

Most Recent Events

  • 26 Mar 2026 According to a Wave Life Sciences media release, additional data from INLIGHT, including data from the 600 mg Phase 1 SAD cohort, are expected in 2026. The company expects to initiate the Phase 2a multidose portion of INLIGHT in individuals with higher BMI and comorbidities in the second quarter of 2026 and initiate new clinical trials evaluating WVE-007 as an incretin add-on and as post-incretin maintenance in 2026.
  • 26 Mar 2026 .According to Wave Life Sciences media release, the first assessment in this portion of the trial is planned for three months after participants have received their first dose.
  • 26 Mar 2026 According to a Wave Life Sciences media release, the company is on track to initiate the Phase 2a multidose portion of INLIGHT evaluating WVE-007 as monotherapy in individuals with higher BMI (35-50 kg/m2) and comorbidities in the second quarter of 2026.

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