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A Phase 1/2 Study of Mirdametinib and Vinblastine for Newly Diagnosed or Previously Untreated Patients With Pediatric Low-grade Glioma and Activation of the MAPK Pathway

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Trial Profile

A Phase 1/2 Study of Mirdametinib and Vinblastine for Newly Diagnosed or Previously Untreated Patients With Pediatric Low-grade Glioma and Activation of the MAPK Pathway

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 21 Feb 2026

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At a glance

  • Drugs Mirdametinib (Primary) ; Vinblastine
  • Indications Glioma
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 16 Jan 2026 Status changed from not yet recruiting to recruiting.
  • 30 Sep 2025 Planned End Date changed from 1 Apr 2035 to 1 Apr 2033.
  • 30 Sep 2025 Planned initiation date changed from 1 Apr 2025 to 1 Dec 2025.

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