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A Randomized Phase II Trial of ASTX727 and Venetoclax Compared With ASTX727, Venetoclax, and Enasidenib for Newly Diagnosed Older Adults With IDH2 Mutant Acute Myeloid Leukemia: A MyeloMATCH Substudy

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Trial Profile

A Randomized Phase II Trial of ASTX727 and Venetoclax Compared With ASTX727, Venetoclax, and Enasidenib for Newly Diagnosed Older Adults With IDH2 Mutant Acute Myeloid Leukemia: A MyeloMATCH Substudy

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 04 Jul 2025

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At a glance

  • Drugs Cedazuridine/decitabine (Primary) ; Enasidenib; Venetoclax
  • Indications Acute myeloid leukaemia
  • Focus Therapeutic Use
  • Acronyms MyeloMATCH

Most Recent Events

  • 10 Apr 2025 Planned initiation date (estimated date of first participant enrollment) changed from 1 Apr 2025 to 27 Dec 2025.
  • 10 Apr 2025 Status changed from not yet recruiting to recruiting.
  • 11 Feb 2025 Planned initiation date changed from 3 Feb 2025 to 1 Apr 2025.

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