Trial Profile

A Phase 1b Study to Assess the Safety, Tolerability, and Pharmacokinetics of ION269 in Adults With Down Syndrome (Hero Study)

Status: Discontinued

Phase of Trial: Phase I

Latest Information Update: 23 Feb 2026

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At a glance

Drugs ION 269 (Primary)
Indications Down syndrome
Focus Adverse reactions
Acronyms Hero study
Sponsors Ionis Pharmaceuticals

Most Recent Events

20 Feb 2026 Status changed from active, no longer recruiting to discontinued.
09 Sep 2025 Status changed from recruiting to active, no longer recruiting.
06 Dec 2024 Planned initiation date changed from 1 Nov 2024 to 1 Jan 2025.

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