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An Open-Label Extension Study to Assess the Safety and Efficacy of Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)

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Trial Profile

An Open-Label Extension Study to Assess the Safety and Efficacy of Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 25 Feb 2026

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At a glance

  • Drugs Vutrisiran (Primary)
  • Indications Amyloidosis; Transthyretin-related hereditary amyloidosis
  • Focus Adverse reactions; Registrational
  • Sponsors Alnylam Pharmaceuticals

Most Recent Events

  • 20 Feb 2026 Planned End Date changed from 30 May 2028 to 31 Mar 2028.
  • 20 Feb 2026 Planned primary completion date changed from 30 May 2028 to 31 Mar 2028.
  • 28 Jul 2025 Planned number of patients changed from 800 to 700.

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