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A Phase 2, Open-Label Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DISC-3405 in Participants With Polycythemia Vera (PV)

Trial Profile

A Phase 2, Open-Label Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DISC-3405 in Participants With Polycythemia Vera (PV)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 16 Sep 2026

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At a glance

  • Drugs 9MW 3011 (Primary)
  • Indications Polycythaemia vera
  • Focus Adverse reactions; Proof of concept
  • Acronyms RESTORE-PV
  • Sponsors Disc Medicine

Most Recent Events

  • 10 Sep 2026 According to a Disc Medicine media release, data from this study expected by the end of 2026.
  • 10 Sep 2026 Results published in the Disc Medicine media release.
  • 31 Aug 2026 According to a Disc Medicine media release, company will give an oral presentation of initial baseline and safety data for N=40 patients from Cohorts A and B, as well as PK, PD, and other efficacy endpoints for the N=20 patients from Cohort A of the RESTORE-PV trial at the SOHO Annual Meeting, which will be held in Houston, Texas on September 9-12, 2026.

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