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A study of TNG462 combinations with two RAS(ON) inhibitors – RAS(ON) multi-selective inhibitor, RMC-6236, and RAS(ON) G12D-selective inhibitor, RMC-9805 (Revolution Medicines) – osimertinib (AstraZeneca) and pembrolizumab (Merck)

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Trial Profile

A study of TNG462 combinations with two RAS(ON) inhibitors – RAS(ON) multi-selective inhibitor, RMC-6236, and RAS(ON) G12D-selective inhibitor, RMC-9805 (Revolution Medicines) – osimertinib (AstraZeneca) and pembrolizumab (Merck)

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 18 Dec 2025

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At a glance

Most Recent Events

  • 04 Nov 2025 According to a Tango Therapeutics media release, there is robust enrollment in this ongoing combination study of vopimetostat + RAS(ON) inhibitors in 2L+ MTAP-del, RAS-mut pancreatic and lung cancer patients. Vopimetostat in combination with either daraxonrasib or zoldonrasib have been well-tolerated to date with exposures in the active range for each compound. Initial data from the Phase 1/2 study are anticipated in 2026.
  • 04 Nov 2025 Status changed from planning to recruiting, according to a Tango Therapeutics media release.
  • 12 May 2025 According to Tango Therapeutics media release, enrollment planned to start in 2Q 2025.

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