Trial Profile

A study of TNG462 combinations with two RAS(ON) inhibitors – RAS(ON) multi-selective inhibitor, RMC-6236, and RAS(ON) G12D-selective inhibitor, RMC-9805 (Revolution Medicines) – osimertinib (AstraZeneca) and pembrolizumab (Merck)

Status: Planning

Phase of Trial: Phase II

Latest Information Update: 26 May 2025

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At a glance

Drugs Daraxonrasib (Primary) ; Osimertinib (Primary) ; Pembrolizumab (Primary) ; TNG 462 (Primary) ; Zoldonrasib (Primary)
Indications Cancer; Solid tumours
Focus Adverse reactions; Therapeutic Use

12 May 2025 According to Tango Therapeutics media release, enrollment planned to start in 2Q 2025.
17 Nov 2024 New trial record
06 Nov 2024 According to Tango Therapeutics media release, enrollment planned to start in 1H 2025.

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