Trial Profile

A Seamless Phase 1/2 Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated Tmod™ CAR T, in Heterozygous HLA-A02 Adults With Recurrent Unresectable, Locally Advanced, or Metastatic Solid Tumors That Express EGFR and Have Lost HLA-A02 Expression

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 07 Jun 2025

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At a glance

Drugs A2B-395 (Primary)
Indications Colorectal cancer; Head and neck cancer; Male breast cancer; Non-small cell lung cancer; Renal cancer; Renal cell carcinoma; Solid tumours; Squamous cell cancer; Triple negative breast cancer
Focus Adverse reactions; Therapeutic Use
Acronyms DENALI-1
Sponsors A2 Biotherapeutics

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