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A Randomized, Double-blind, Sponsor-open, Placebo-controlled Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Single and Multiple Ascending Doses of ORX142 in Healthy Adults, Single Doses of ORX142 in Healthy Older Adults, and a Single Dose Crossover, Proof-of-concept Study of ORX142 in Acutely Sleep-deprived Healthy Subjects

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Trial Profile

A Randomized, Double-blind, Sponsor-open, Placebo-controlled Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Single and Multiple Ascending Doses of ORX142 in Healthy Adults, Single Doses of ORX142 in Healthy Older Adults, and a Single Dose Crossover, Proof-of-concept Study of ORX142 in Acutely Sleep-deprived Healthy Subjects

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 20 Jan 2026

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At a glance

  • Drugs ORX 142 (Primary)
  • Indications Hypersomnia
  • Focus Adverse reactions; First in man; Proof of concept
  • Sponsors Centessa Pharmaceuticals

Most Recent Events

  • 24 Dec 2025 Planned End Date changed from 31 Dec 2025 to 15 Jun 2026.
  • 24 Dec 2025 Planned primary completion date changed from 31 Dec 2025 to 15 Jun 2026.
  • 04 Jul 2025 According to a Centessa Pharmaceuticals media release, company announces that it will receive US$4.8 million in milestone payments from Centessa Pharmaceuticals to initiate development of of this phase 1 trial.

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