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A Phase 1/2 Open-Label, Single-Ascending-Dose Study of EN-374, a Helper-Dependent Adenoviral-Based Gene Therapy, in Participants with X-Linked Chronic Granulomatous Disease

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Trial Profile

A Phase 1/2 Open-Label, Single-Ascending-Dose Study of EN-374, a Helper-Dependent Adenoviral-Based Gene Therapy, in Participants with X-Linked Chronic Granulomatous Disease

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 24 Aug 2026

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At a glance

  • Drugs Gene therapies (Primary)
  • Indications Chronic granulomatous disease
  • Focus Adverse reactions
  • Sponsors Ensoma

Most Recent Events

  • 21 Aug 2026 Status changed from recruiting to active, no longer recruiting.
  • 08 May 2026 According to Ensoma media release, the data from the trial will be presented at the American Society of Gene & Cell Therapy (ASGCT) 29th Annual Meeting, 2026.
  • 10 Dec 2025 According to Ensoma media release, pediatric participants would be enrolled in a dose-expansion cohort, after completion of the adult cohorts.

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