Trial Profile

A Phase 1/2 Open-Label, Single-Ascending-Dose Study of EN-374, a Helper-Dependent Adenoviral-Based Gene Therapy, in Participants with X-Linked Chronic Granulomatous Disease

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 18 Mar 2026

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At a glance

10 Dec 2025 According to Ensoma media release, pediatric participants would be enrolled in a dose-expansion cohort, after completion of the adult cohorts.
10 Dec 2025 According to Ensoma media release, the company has received U.K. Medicines and Healthcare Products Regulatory Agency (MHRA) clearance of the CTA application for its lead program EN-374.
01 Dec 2025 According to Ensoma media release, the first patient has been dosed in this study.

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