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A Phase 1/2 Open-Label, Single-Ascending-Dose Study of EN-374, a Helper-Dependent Adenoviral-Based Gene Therapy, in Participants with X-Linked Chronic Granulomatous Disease

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Trial Profile

A Phase 1/2 Open-Label, Single-Ascending-Dose Study of EN-374, a Helper-Dependent Adenoviral-Based Gene Therapy, in Participants with X-Linked Chronic Granulomatous Disease

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 12 Dec 2025

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At a glance

  • Drugs Gene therapies (Primary)
  • Indications Chronic granulomatous disease
  • Focus Adverse reactions
  • Sponsors Ensoma

Most Recent Events

  • 01 Dec 2025 According to Ensoma media release, the first patient has been dosed in this study.
  • 22 Sep 2025 According to Ensoma media release, the company announced the closing of a $53 million financing from its existing syndicate of top-tier investors. The financing will support this trial and support key clinical readouts.
  • 08 Aug 2025 Status changed from not yet recruiting to recruiting.

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